A groundbreaking study led by Dr. Ignacio Larrabide and collaborators from Yatiris (Instituto Pladema, UNICEN-CONICET) introduces a new 3D analysis methodology that quantifies shape and positional changes in Woven Endo-Bridge (WEB) devices following aneurysm treatment. Using 3D rotational angiography (3DRA) imaging, this innovative technique precisely measures key parameters such as the WEB device’s volume, surface area, and positional dynamics over time.

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Understanding the long-term behavior of WEB devices is critical for improving patient care. These insights help physicians better predict how devices adapt within treated aneurysms, leading to more precise treatment planning and improved outcomes.

“This new methodology offers a detailed, data-driven approach to understanding the interaction between WEB devices, aneurysms, and blood flow,” said Dr. Larrabide, the lead researcher. “By combining 3D analysis with computational fluid dynamics (CFD) simulations, we provide a comprehensive picture of how these devices perform over time, ultimately empowering clinicians to make more informed decisions.”

Methodology Overview

The research uses 3DRA imaging to analyze how the WEB device interacts with vascular structures post-implantation. By accurately measuring changes in the device’s geometry at 6 and 12 months, the study identifies critical insights into:

• Volume and Surface Area Modifications: Quantifying structural changes in the WEB device as it adapts within the aneurysm.
• Positional Shifts: Understanding how the device stabilizes and integrates with the vascular anatomy.
• Flow Dynamics: Using CFD simulations to evaluate how these changes impact blood flow and treatment efficacy.

Broader Implications for Healthcare

The findings provide a comprehensive roadmap for improving patient outcomes, optimizing healthcare resources, and driving innovation in neurovascular care.
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Implications for Healthcare Systems
For Medical Professionals - The findings offer a roadmap for improving patient outcomes and operational efficiency:

• Enhanced Planning: Physicians gain a better understanding of how WEB devices behave over time, allowing for more personalized and effective treatment strategies.
• Reduced Risks: Insight into device stability reduces the likelihood of complications or retreatments.
  

Opportunities for Medical Device Manufacturers
For Medical Device Manufacturers -The study also presents significant opportunities for device manufacturers to innovate and lead in the neurovascular market:

• Innovation Opportunities: Data-driven insights into device performance inform design refinements and new product development.
• Market Leadership: Demonstrating the long-term value of WEB devices enhances credibility and competitiveness in the neurovascular field.

Value for Healthcare Administrators
For Healthcare Systems - Administrators stand to gain from adopting these findings into their institutional practices:

• Improved Patient Outcomes: By optimizing device selection and implantation strategies, the research enhances long-term success rates, benefiting both patients and providers.
• Cost-Efficiency: Minimizing complications and retreatments leads to significant cost savings and more effective resource utilization.

Driving Innovation in Post-Treatment Aneurysm Care

The integration of morphology analysis and CFD simulations represents a transformative approach in understanding and enhancing the performance of intrasaccular devices like WEB. These findings offer actionable insights that not only deepen our understanding of aneurysm treatment but also have the potential to significantly refine clinical decision-making. By leveraging advanced 3D analysis and CFD simulations, this research bridges the gap between innovation and clinical practice.

“These findings not only provide a new way to assess WEB device performance but also highlight the critical role of innovation in improving patient outcomes,” said Dr. Ignacio Larrabide. He and his team emphasized the collaborative nature of this achievement, stating, “The ultimate goal of this research is to enhance the tools available to physicians, improve outcomes for patients, and drive innovation in neurovascular treatment. Collaboration between research, clinical practice, and industry is essential to achieving these outcomes.”

Collaborators Kevin Janot, Aymeric Rouchaud, and Ana Paula Narata underscored the broader implications of this methodology, emphasizing its potential to redefine post-treatment care strategies and improve long-term patient outcomes.

This study exemplifies the importance of integrating advanced computational techniques with clinical research to optimize patient care and propel the neurovascular field forward. For healthcare professionals, device manufacturers, and administrators, it represents a significant step toward aligning treatment strategies with the principles of precision medicine.

These insights are being integrated by Mentice's research team into the development of intrasaccular devices with Ankyras. This new approach introduces a fresh concept for device sizing, aiming not only to predict immediate device behavior but to provide a full and accurate range of data for better device selection and improved patient outcomes. Click here to learn more about Ankyras and Mentice's research-driven innovations.  

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About the Research Team

This study was led by Dr. Ignacio Larrabide in collaboration with Kevin Janot, Aymeric Rouchaud, and Ana Paula Narata, who collectively emphasized the transformative potential of this methodology to refine post-treatment care strategies and improve long-term outcomes for patients.

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Contact Information

For more details about this study or to discuss collaborative opportunities, please contact:

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