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Ankyras
Clinical Research & Publications

ANKYRAS
Neurovascular
Modification of Woven Endo-Bridge After Intracranial Aneurysm Treatment: A Methodology for Three-Dimensional Analysis of Shape and Relative Position Changes

Purpose: During follow-up of patients treated with WEB devices, shape changes have been observed. The quantitative three-dimensional measurement of the WEB shape modification (WSM) would offer useful information to be studied in association with the anatomical results and try to better understand mechanisms implicated in this modification phenomenon.

Ann Biomed Eng 52, 1403–1414 (2024). https://doi.org/10.1007/s10439-024-03465-5
February 24, 2024
ANKYRAS
Neurovascular
Porosity distribution upon the surface of a deployed flow diverter: an experimental and simulation study

Flow diverters are widely extended in clinical practice for intracraneal aneurysms treatment. They are formed by a dense mesh of braided wires that partially occludes the aneurysm neck and restores the blood flow into the parent vessel. The occlusion degree is highly dependant on the distribution of the wires under the aneurysm, which is affected by the vessel geometry. Nowadays, there are no clinical indicators of the covering ratio once the flow diverter is deployed.

Proceedings of the SPIE, Volume 10160, id. 101601C 10 pp. (2017).
ANKYRAS
Neurovascular
Simulation of intra-saccular devices for pre-operative device size selection: Method and validation for sizing and porosity simulation

Intra-saccular devices (ID) are novel braided devices used for complex intracranial aneurysms treatment. Treatment success is associated with correct device size selection. A technique that predicts the ID size within the aneurysm before intervention will provide a powerful computational tool to aid the interventionist during device selection.

Comput Biol Med . 2022 Aug;147:105744.
ANKYRAS
Neurovascular
Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data

Flow-Diverter (FD) porosity has been pointed as a critical factor in the occlusion of cerebral aneurysms after treatment. Objective: Verification and Validation of computational models in terms of predictive capacity, relating FD porosity and occlusion after cerebral aneurysms treatment.

Front Med Technol . 2021 Sep 17;3:705003
ANKYRAS
Neurovascular
Intra-saccular device modeling for treatment planning of intracranial aneurysms: from morphology to hemodynamics

Intra-saccular devices (ID), developed for the treatment of bifurcation aneurysms, offer new alternatives for treating complex terminal and bifurcation aneurysms. In this work, a complete workflow going from medical images to post-treatment CFD analysis is described and used in the assessment of a concrete clinical problem.

Int J Comput Assist Radiol Surg . 2021 Oct;16(10):1663-1673
ANKYRAS
Neurovascular
Early Results in Flow Diverter Sizing by Computational Simulation: Quantification of Size Change and Simulation Error Assessment

Sizing of flow diverters (FDs) stent in the treatment of intracranial aneurysms is a challenging task due to the change of stent length after implantation

Oper Neurosurg (Hagerstown) . 2018 Nov 1;15(5):557-566.
ANKYRAS
Neurovascular
Deployment of flow diverter devices: prediction of foreshortening and validation of the simulation in 18 clinical cases

Flow diverter (FD) devices show severe shortening during deployment in dependency of the vessel geometry. Valid information regarding the geometry of the targeted vessel is therefore mandatory for correct device selection, and to avoid complications. But the geometry of diseased tortuous intracranial vessels cannot be measured accurately with standard methods. The goal of this study is to prove the accuracy of a novel virtual stenting method in prediction of the behavior of a FD in an individual vessel geometry.

Neuroradiology . 2019 Nov;61(11):1319-1326.
ANKYRAS
Neurovascular
ID-Fit: Intra-Saccular Device Adjustment for Personalized Cerebral Aneurysm Treatment

Intrasaccular devices, like Woven EndoBridge (WEB), are novel braided devices employed for the treatment of aneurysms with a complex shape and location, mostly terminal aneurysms. Such aneurysms are often challenging or impossible to treat with other endovascular techniques such as coils, stents, flow diverter stents.

Springer International Publishing, Medical Image Computing and Computer Assisted Intervention – MICCAI 2020
ANKYRAS
Neurovascular
Porosity distribution upon the surface of a deployed flow diverter: an experimental and simulation study

Flow diverters are widely extended in clinical practice for intracraneal aneurysms treatment. They are formed by a dense mesh of braided wires that partially occludes the aneurysm neck and restores the blood flow into the parent vessel. The occlusion degree is highly dependant on the distribution of the wires under the aneurysm, which is affected by the vessel geometry. Nowadays, there are no clinical indicators of the covering ratio once the flow diverter is deployed. We propose a novel method for the simulation of the flow diverter local porosity before its deployment into the parent vessel. We validate the method on curved silicon models, obtaining a correlation of 0.9 between the simulated values and the measured porosity on the deployed flow diverter.

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Disclaimer & Regulatory Information

Ankyras is manufactured by Mentice Spain S.L. and distributed by Mentice subsidiaries and partners in approved markets.
Mentice Spain SL: Mentice Spain SL has obtained the ISO 13485 certification with number MD 784027
Ankyras certifications: The Ankyras product complies with the Medical Device Regulation (EU CE Mark, MDR 784032) and the UK Conformity Assessed (UKCA 784033)